The severe shortage of organs for transplantation and the continual reluctance of the public to voluntarily donate has prompted consideration of alternative strategies for organ procurement. This paper explores the development of market approaches for procuring human organs for transplantation and considers the social and moral implications of organ donation as both a gift of life and a commodity exchange. The problematic and paradoxical articulation of individual autonomy in relation to property rights and marketing human body parts is addressed. We (...) argue that beliefs about proprietorship over human body parts and the capacity to provide consent for organ donation are culturally constructed. We contend that the political and economic framework of biomedicine, in western and non-western nations, influences access to transplantation technology and shapes the form and development of specific market approaches. Finally, we suggest that marketing approaches for organ procurement are and will be negotiated within cultural parameters constrained by several factors: beliefs about the physical body and personhood, religious traditions, economic conditions, and the availability of technological resources. (shrink)

Studies on informed consent to medical research conducted in low or middle-income settings have increased, including empirical investigations of consent to genetic research. We investigated voluntary participation and comprehension of informed consent among women involved in a genetic epidemiological study on breast cancer in an urban setting of Nigeria comparing women in the case and control groups.

In 1785, George Washington described a “knowing farmer” as “one who can convert every thing he touches into manure, as the first transmutation towards Gold.” With these words, Washington linked the “knowing farmer” to the alchemist who endeavored to transform base metals into gold with the aid of a philosopher's stone. In each instance, the challenge was to convert raw materials into something new and precious.Today, the “knowing bioethicist” is in a similar position. American bioethics harbors a variety of ethical (...) methods that emphasize different ethical factors, including principles, circumstances, character, interpersonal needs, and personal meaning. Each method reflects an important aspect of ethical experience, adds to the others, and enriches the ethical imagination. (shrink)

A medical information commons is a networked data environment utilized for research and clinical applications. At three deliberations across the U.S., we engaged 75 adults in two-day facilitated discussions on the ethical and social issues inherent to sharing data with an MIC. Deliberants made recommendations regarding opt-in consent, transparent data policies, public representation on MIC governing boards, and strict data security and privacy protection. Community engagement is critical to earning the public's trust.

Clinical next generation sequencing is a term that refers to a variety of technologies that permit rapid sequencing of large numbers of DNA segments, up to and including entire genomes. As an approach that is playing an increasingly important role in obtaining genetic information from patients, it may be viewed by public and private payers either positively, as an enabler of the promised benefits of personalized medicine, or as “the perfect storm” resulting from the confluence of high market demand, an (...) uproven technology, and an unprepared delivery system. A number of recent studies have noted that coverage and reimbursement will be critical for clinical integration of NGS, yet the evidentiary pathway for payer decision-making is unclear. Although there are multiple reasons for this uncertain reimbursement environment, the situation stems in large part from a long-standing lack of alignment between the information needs of regulators and post-regulatory decision-makers such as payers. (shrink)

In this essay, I attempt to solve the problem of the existence of evil in a world created by an omniscient, omnibenevolent, omnipotent God. I conclude that evil exists because God wanted to create moral creatures. Because choice is necessary for morality, God created creatures with enormous capacities for choice—and therefore enormous capacities for evil. Material creatures are subject to pain and death because, for such creatures, moral choices are deeply serious. The laws that underlie the material world and from (...) which material life arises are such that, from their workings out on a planet that can support life, natural evils happen. (shrink)

This paper examines the connection between model-theoretic truth and necessary truth. It is argued that though the model-theoretic truths of some standard languages are demonstrably ''''necessary'''' (in a precise sense), the widespread view of model-theoretic truth as providing a general guarantee of necessity is mistaken. Several arguments to the contrary are criticized.

This paper considers the ethical implications of applying three major ethical theories to the memory structure of an artificial companion that might have different embodiments such as a physical robot or a graphical character on a hand-held device. We start by proposing an ethical memory model and then make use of an action-centric framework to evaluate its ethical implications. The case that we discuss is that of digital artefacts that autonomously record and store user data, where this data are used (...) as a resource for future interaction with users. (shrink)

Abstract:This essay suggests that the word decolonial offers analytic power for feminist historians of women. As a category, it creates interpretive space for female experience beyond the elite/subaltern binary, where arguably most women live and work in the modern period. As a reading practice, the decolonial fosters intellectual awareness of social and intellectual practices that neither address the state, as in “anti-imperialism,” nor proffer counter nationalism or counter racialization as responses to coloniality. Offering examples from the archive, the media, and (...) teaching, this essay describes the decolonial as a productive site of women's agency in domains all too easily overlooked when historians focus on the conventional categories of state and nation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Truth Will Set You Free, or How a Troubled Philosophical Theory May Help to Understand How People Talk About Their AddictionPatricia A. Ross (bio)Keywordsveridicality of narrative, contingency of theories, belief-behavior, causal connectionConsider the following proposition: If one were to recognize the unsatisfactory implications of maintaining a certain theoretical position, one would thereby be motivated to accept a more adequate theory, which would alter one's beliefs and, in turn, (...) alter the behaviors that are based upon those beliefs. Faith in this proposition is what motivates many of us to teach. But, alas...Allison Mitchell's argument for rethinking addiction intervention—in particular, rethinking twelve-step programs—is premised on this proposition. According to her argument, addicts function with an impoverished sense of self that is reflective of a grossly simplified form of philosophical materialism. By recognizing the limitations of this philosophically unconvincing view, and by, in effect, accepting a better, more complete materialism, addicts can come to modify their self-conception. This modification is instrumental to recovery.A careful consideration of the chain of events being proposed, and the problems with it, is helpful for understanding the limitations of her argument. There are four points that I consider in turn: (1) considering narratives can tell us something about the self-conception of addicts, (2) philosophical materialism can help us to understand and explain something about an addict's self-conception and how it is inadequate, (3) this sense of self is distinct from nonusers and the way in which it is distinct helps to understand the problem of addiction, and (4) a change in self-conception with respect to materialism helps recovery and, thus, our best intervention is one based on having addicts accept a full materialist theory of the self and not a pretheoretic one. [End Page 227]With respect to the first point, it should be noted that Mitchell's overall argument does not depend on whether or not it is true that narratives of addiction tell us something veridical about the self-conception of addicts. Such narratives may simply provide us with a potential theory—a possible worlds scenario—of how addicts conceive of themselves. Mitchell points this out herself. The narratives and the interpretation that she provides of these narrative, "are meant only to highlight a certain pattern of self-expression and conception that may in fact be common in persons who use mind-altering substances; the readings do not establish any empirical matters of fact or philosophical truths, nor do they prove any conclusions about how such persons (must) express themselves or conceive their nature" (Mitchell 2006, 214).Thus, what the argument is actually concerned with are the theoretical claims about the self-conception of addicts that are garnered from these narratives. Nevertheless, because the narratives provide the starting point for Mitchell's argument, it is worth thinking carefully about the epistemic status of this body of literature. In particular, could a consideration of such literature lead us astray in our endeavors to understand how addicts might misconceive of themselves and, if so, in what way? What sort of epistemic status does this information hold?Mitchell is motivated by Wittgensteinian analyses of the relationship between thought and language. The particular idea that she employs from Wittgenstein is that every act of self-expression, whether it is verbal or written narrative, reveals something about the conceptual framework with which the author is working. Thus, one can learn about the author of a narrative—one can acquire a sense of how that individual conceives of him- or herself—by looking at the language that is employed to talk about and describe him- or herself.Mitchell enumerates some problems with this approach. She mentions that the author may fail to make his or her intended sense clear to readers; that the reader's narrative expectations determine the interpretation given to the narrative; that literary narrative may be less direct, less ordinary than everyday uses of language; and that interpreting such narrative via philosophical framework may ascribe to people positions that are more precise and sophisticated than they actually intend (p. 213).Aside from these quite serious problems, it is necessary to recognize... (shrink)

In many ways, Roe v. Wade marked a new chapter in American life. By assuring women of greater reproductive freedom., It gave women greater economic and social freedom, Inflamed a partisan battle between pro-life and pro-choice camps, and provoked a public debate regarding the proper sphere of judicial action. Hence, just as Roe has been critical to the changing politics of gender, it has been the focus of a political debate about the meaning of personhood and morality of abortion, the (...) scope of individual freedom, and the judiciary's role in effecting social change. (shrink)

A proof of pragmatism is proposed in Peirce's 1903 lecture series on Pragmatism as a Principle and Method of Right Thinking. It is necessary first to define what pragmatism is, a task for which a practitioner of the pragmatic maxim would be fitted, but which, however, must be highly problematic to a potential practitioner who does not yet know its full meaning. In order to clarify its meaning, Peirce uses a method he recommends for such conundrums in his 1891 article, (...) “The Architecture of Theories,” that is, “to make a systematic study of the conceptions out of which a philosophical theory may be built, in order to ascertain what place each conception may fitly occupy in such a theory and to what uses it is adapted”. Peirce's systematic study of the basis of logic and pragmatism in relation to it begins to appear around 1898 and peaks in 1903 when pragmatism's definition and role within the sciences is established in these lectures. (shrink)

Richard C. Atkinson’s eight-year tenure as president of the University of California reflected the major issues facing California itself: the state’s emergence as the world’s leading knowledge-based economy and the rapidly expanding size and diversity of its population. As this selection of President Atkinson’s speeches and papers reveals, his administration was marked by innovative approaches that deliberately shaped U.C.’s role in this changing California. These writings tell the story of the national controversy over the SAT and Atkinson’s successful challenge to (...) the dominance of the seventy-five-year-old college entrance examination. They also highlight other issues with national significance: U.C.’s experiments with race-neutral admissions programs; the challenges facing academic libraries and the University’s pioneering activities with the California Digital Library; and the University’s involvement in new paradigms of industry-university research. Together, these speeches and papers open a window on an eventful period in the history of the nation’s leading public research university and the history of American higher education. (shrink)

A comprehensive look at fictive letters in Greek literature from Homer to Philostratus, first published in 2001. It includes both embedded epistolary narratives in a variety of genres, and works consisting solely of letters, such as the pseudonymous letter collections and the invented letters of the Second Sophistic. The book challenges the notion that Ovid 'invented' the fictional letter form in his Heroides and considers a wealth of Greek antecedents for the later European epistolary novel tradition. Epistolary technique always problematizes (...) the boundaries between fictionality and reality. Based on a process of selection and self-censorship, the letter is a construction, not a reflection, of reality. The author bypasses the question of sincerity for a close look at epistolary self-representation, the function of the letter form and the nature of the relationship between writer and reader in a wide range of ancient Greek texts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Fact Value Dichotomy in Demarcating DisorderPatricia A. Ross (bio)Keywordsdemarcation, values, ontology, epistemologyHaving read numerous articles on the concept of mental disorder, I find it useful to approach new articles on the topic by first sketching out the conceptual framework within which each author places the problem. The goal in doing this is not merely to be able to compare ideas within a remarkably diverse discussion, but also to (...) be able to uncover any presuppositions that underlie the account, as well as assumptions necessary for the argument, which may or may not be warranted. By approaching each new offering in this way, I often find that the solutions proposed depend a great deal on these undisclosed features, and that such presuppositions and assumptions are often questionable, at best, and are sometimes simply unwarranted. Brülde's discussion of mental disorder and values provides a useful example of this method.To determine how we should draw the line between disorder and nondisorder (henceforth, I refer to this as demarcation), Brülde claims that we need to address four questions. We need to determine (1) the extent to which demarcation depends on values and the extent to which it is descriptive, (2) the kinds of values we need to make use of (aesthetic, moral, pragmatic), (3) whether there is an implicit reference to some specific evaluative standard, and (4) whether the value judgments used to demarcate are ontological or epistemological. In putting forth these questions, Brülde identifies what he takes to be the generally agreed upon claim that there are two components necessary for demarcation: a factual component and an evaluative component. These components are distinct from each other and both are necessary—the demarcation cannot be made "by objective means alone," nor is it purely evaluative. Thus, demarcation necessarily involves a distinct value component, and the answers to Brülde's four questions are intended to shed light on how values are involved in determining the evaluative component of demarcation.Working under the assumption that they are distinct, Brülde sets aside discussion of the factual component to focus on the value component. He also tables the first of his four questions (the extent to which demarcation depends on values and the extent to which it is descriptive), citing an over-abundance of literature on the matter. Having thus framed the problem, Brülde turns his full attention to questions two through four, ultimately providing us with the answer that the values needed to demarcate disorders from nondisorders are of several types; mental disorder is both implicitly and explicitly an evaluative term, as well as value laden in both the ontological and epistemic senses. This [End Page 107] framing of the problem provides us with insight into the underlying presuppositions and assumptions that lead to Brülde's conclusion.The first aspect of this framework to consider is the division of demarcation into two distinct components, and the setting aside of the factual component as distinct from, and inconsequential to, the questions concerning values. By proceeding in this way, Brülde's argument rests on the presupposition that we can, and want, to consider the value component in isolation from the factual component. This presupposition raises a number of questions. Is there nothing about the factual component that may help us in our consideration of the value component, or vice versa? Does the factual component confine what we can say or know about the value component in any way. Overall, some justification is needed for accepting that there are two distinct and independent components, as well as for believing that the factual component can be disregarded in this way.Brülde also makes the (explicit) assumption that there is some internal state or process underlying all mental disorders about which we have or will gain factual knowledge that is objective. Implicit in this is the further assumption that this knowledge (regarding internal states or processes) will be all there is to say, scientifically, about the disorder—that is, knowledge concerning internal states and processes are what will comprise the "factual component." But if we can have sociological facts and psychological facts (and I think it is... (shrink)

Hegel says that the task of the philosopher in history is to follow the trace of Reason in history, to discern the realization of the freedom which Spirit is. Hegel’s own discerning of Reason in history is tinged with a teleological optimism which is unconfirmed and perhaps even denied by history. This does not mean that the task which Hegel presents should be set aside. Today’s philosopher must still attempt to understand history. The question which seems to focus present attempts (...) to do so is: How can an understanding of history provide us with a grasp of the world in which we live so that we can do what is possible to provide that world with a future? This question reflects a strong sense of finitude. Yet, the questions which guide Hegel are very similar: What is the relation of the finite and the infinite? How does this relation appear on the scene in history? (shrink)

Human Specialization in Design and Technology explores emerging trends in learning and training-standardization, customization, personalization-with a unique focus on human needs and conditions. Analyzing evidence from current academic research as well as the popular press, this concise volume defines and examines the trajectory of instructional design and technologies toward more human-centered and specialized products, services, processes, environments, and systems. Examples from education, healthcare, business, and other sectors offer real-world demonstrations for scholars and graduate students of educational technology, instructional design, ICT, (...) and business development. (shrink)